The Myostatin Project - Part 2 By Tim Patterson Note: If you haven't read Part 1 of The Myostatin Project, I suggest you do. Otherwise you'll be missing important background information that leads directly into Part 2. The Medicine Man's Hydroponic Farm The location: The Canary Islands... more specifically, a high-tech lab, which is nestled among several species of marine algae growing under strict controls in a hydroponic farm. And heading the lab is our very own Medicine Man, who's not just in charge of harvesting wild algae out of the ocean. No, we have him on a mission that's far more complex and advanced than that. The research started with natural organisms, of course, but that's where nature stopped and science began to change things rather dramatically. For the last two years, at our request, the Medicine Man has been manipulating growing conditions in order to produce super strains of algae, which contain extremely high concentrations of certain compounds that are very potent and highly active in the body. The primary focus of the lab has been on next-generation antioxidants for potential drug applications, but the Medicine Man always has his mental radar turned on, looking for one of those accidental breakthroughs I mentioned before. As it happened, one of his lab assistants was analyzing a rare form of marine algae, called Cystoseira canariensis, extracting its component parts, and testing the actions of each fraction. During an experiment, the assistant discovered a phlorochemical compound that presents a structure which is similar to a known myostatin binder. Realizing the incredible potential of this finding, the research team immediately designed a series of tests to evaluate the myostatin-binding affinity of the compound. If proven, this discovery would body slam sports science into a speechless stupor, and the data would need to be dead-on accurate. So the researchers thoroughly investigated the scientific literature to make sure all of the analytical methodologies were in line with current technology. The lab then procured the appropriate cell cultures and other materials and began the experiment. The first step was isolating myostatin through an established method. This was accomplished by flowing a crude muscle homogenate (liquefied muscle in a buffering solution) through various chromatography columns, the final of which contained a known myostatin binder, called heparin sepharose. If successful, the heparin would isolate myostatin by binding to it and allow the rest of the material to pass by unaffected. The last step of the isolation process is a chemical reaction that causes the bound myostatin to be eluted (released) and collected. (Note: Heparin is a mucopolysaccharide produced by the body that's responsible for keeping your blood from clotting. It's also used as a medicine to thin the blood. Ingesting heparin in the amounts required to effectively bind myostatin as a performance aid would be deadly.) To establish if myostatin had actually been isolated, the eluate from the first experiment was analyzed, using Western-blot immuno-electrophoresis, which positively identified the compound as myostatin. In other words, the experiment was a success. We did indeed isolate myostatin by using heparin as a binder. Next, the entire two-phase process was repeated, except this time the heparin-sepharose column was replaced with a column containing a fraction of our newly discovered compound extracted from Cystoseira. If this last step yielded pure myostatin, it would mean that we actually found an effective way to bind myostatin, using a safe "dietary supplement." Well, what happened amazed everyone. Our extracted compound actually shows a greater affinity than heparin for binding myostatin! That's incredible! It's stronger and works better. This is just the beginning, though. We're currently moving on to phase two of our research, which includes a series of studies that will culminate with human-performance trials. But at this point in our research, we're extremely excited. We believe we're on the cusp of something much greater than anyone can fathom. Effectively, we've taken the governor off genetic limitations to muscle growth, making it possible for the "average" human to become, well, "super-human." I truly believe that this is one of those rare times when everyone from scientists to athletes is going to be blown away - that when all is said and done, bodybuilding and sports in general will be changed in an incredibly positive way, forever. Regarding the actual active component extracted from cultured Cystoseira, it's a low-molecular weight sulfo-polysaccharide, called CSP-3. The compound is highly water-soluble with great bioavailability. In other words, we have every belief that CSP-3 will easily get into the body's bloodstream intact and effectively bind (neutralize) significant amounts of myostatin. CSP-3... Can I Get It? At this point, I'm sure most of you are about ready to blow a fuse with excitement. You want the stuff, now! You're thinking: "When will this happen? Next month? Next year?" When, if ever, will I be able to get my hands on CSP-3? Determining when to manufacture CSP-3 has been on my mind for quite some time. I've made a decision, but it wasn't nearly as easy as you might think. Of course, if I would've based my conclusion upon feedback from readers, well, there'd be no question. For every 100 "go for it" responses I received, there were only three that voted to wait for further research. But like I said, it's a little more complicated than that. Here's how I see it: 1) We have proven that we've isolated a highly potent, yet safe, myostatin binder, called CSP-3. 2) CSP-3 is orally bioavailable and well tolerated by the body. 3) Muscle-mass gains attained by inhibiting myostatin are much slower and different than with pro-steroids or steroids, which means it'll take additional time to get through more-extensive research to determine exactly what kind of muscle-building results are possible. We know CSP-3 works, we're just excited to know how big the average user can get, and what the rate of gain is. 4) Inhibiting myostatin won't affect the heart or structures other than skeletal muscle, making it very safe. In fact, it's not only safe, it's healthy. In a study funded by the National Institutes of Health and conducted at Johns Hopkins University, researchers Lee and McPherron found that inhibiting myostatin is potentially an effective way to "prevent or treat obesity and associated conditions, like diabetes." Just about everyone who has ever heard of myostatin has dreamed of the day when it could be inhibited, so the pressure to release CSP-3 is tremendous. We know CSP-3 is safe and it works, so why not go ahead and manufacture it? At this point, I believe delaying public access solely to gain more knowledge just wouldn't be the right thing to do. So, I've decided to release the product now, but we have a pretty big problem to overcome: CSP-3 is contained in a remarkably rare and temperamental strain of cultured Cystoseira, which makes commercial production impossible without the use of our precisely controlled, hydroponic farm to maintain ideal growing conditions. This means that, until we find a way around the situation, supplies are going to be extremely limited. This limitation, coupled with the outrageous demand that's already exploding for CSP-3, will result in a shortage of the material. Remember, we can't just use regular Cystoseira. We have to grow, harvest, and extract a special strain that's specifically cultured to yield super-high concentrations of CSP-3. So once you begin taking CSP-3, you should make sure you have enough to last at least two months before you start. You need to use CSP-3 a minimum of 60 days to begin seeing the effects, and if you don't have enough on hand, you very well could run out and not be able to get additional supplies for several weeks. We'll do the best we can to maintain adequate inventory levels, but I guarantee, we'll run out from time to time. It's inevitable. I'm not just telling you this so that we can sell more CSP-3, either. It's no different than if you were to completely shut off the myostatin gene; it would take at least a couple of months before you'd begin to notice the effects. So unless you're truly committed to sticking with the program and using CSP-3 for a minimum of two months, don't begin taking it. Don't waste your money or our very limited supply of CSP-3. But if you want to completely revolutionize your physique, make no mistake about it, binding and thus inhibiting myostatin is very powerful medicine that produces three incredible effects that nothing else can deliver: Formation of New Muscle. Instead of causing muscles to grow larger through hypertrophy, you're actually forming brand-new muscle cells that will develop and incorporate into existing, mature muscle. And the longer you take CSP-3 (inhibit myostatin), the more new muscle mass you'll accumulate. Imagine that, actually accumulating muscle! Also, by increasing the actual number of muscle cells, the rate at which you actually grow will begin to accelerate over time, resulting in bigger and much faster gains! Permanent Muscle Gains. Most of the time, gaining muscle is at best, three steps forward and two steps backward. This is because you're increasing muscle mass in a hyper-anabolic environment (in the body), which can't be sustained ad infinitum. Newly formed muscle cells, on the other hand, are permanent. This doesn't mean that the resulting muscle mass can't atrophy, but it does mean it can't disappear. It's for keeps! Automatic Decrease in Body Fat. All of the animal studies show that decreased myostatin levels result in a lot less body fat. In fact, the study I mentioned earlier shows that animals with lower myostatin levels have anywhere from 33-50% less body fat, regardless of diet! Researchers indicate that this may be due to increased insulin sensitivity in skeletal muscle that's brought about by low levels of myostatin. Bottom line, if you neutralize the effects of myostatin long enough, you can literally attain a much more-muscular, and leaner, condition that otherwise wouldn't be possible. Of course, to maximize results, you have to eat optimally for gaining muscle mass and train hard. I can't stress this point enough. You can't just take a pill - any pill or injection, or anything else, for that matter - and get the physique you want. You have to work hard at it, be disciplined, and give it time. And something else many of you are already thinking that should be mentioned is, if you include powerful anabolic compounds, like MAG-10, the entire building process is substantially accelerated. Binding myostatin in a super-anabolic environment is the way to go if you want maximum gains in the shortest amount of time. So, if you can afford it, I recommend that you go through a two-week MAG-10 cycle at least once every six weeks while using CSP-3. If you don't want to use MAG-10, still follow the "MAG-10 Plan for Success" guidelines, except decrease total calories by 500 per day during the gaining phase. MYOSTAT Super-Transforming Growth Factor Taking the governor off muscle-mass limitations is now possible with Biotest's brand-new supplement, called MYOSTAT Super-Transforming Growth Factor. Each bottle of MYOSTAT costs contains 40, 500-mg capsules of the special, myostatin-binding sulfo-polysaccharide CSP-3. And like all Biotest supplements, MYOSTAT has a 100% money-back guarantee, so there's no real risk on your part. Only start the program if you're committed to sticking with it for a minimum of two months. We truly live in incredible times. I never thought the day would come so soon when we could actually neutralize the effects of myostatin in humans. Well, it's here - big time - ready to set you free from the gene that stands between you and your physique dreams. We believe that MYOSTAT is going to redefine and change the muscle-building world forever! In fact, when it comes to building the ultimate physique, it could very well be one of the most important discoveries ever made. Think about it. Now you can successfully overcome the single biggest limiting factor - genetics! Why wouldn't you want to experience it firsthand? Nandrosol Sports Skin Tonic Written By Tim Patterson, Biotest Laboratories Formulated into a crystal-clear, topical skin spray, Nandrosol provides ultra-pure (purified through a proprietary filtration system) 19-norandrostenediol. Each 240-ml (8-ounce) bottle of Nandrosol contains 12 grams of 19-norandrostenediol (50 mg/ml). One bottle can last between 12 days (heavy use) and 30 days (moderate use). Nandrosol 19-Norandrostenediol Sports Skin Tonic by Tim Patterson Nandrosol Is Here! Great Muscle Gains, but Safe? "Do I, or don't I? Is it safe or not? Hmm... I'm going nuts trying to figure this thing out. It's got me gridlocked in indecision..." Have you been sitting on the sidelines trying to determine how to take prohormones without the worry of negative side effects? Hair loss. Gyno. Prostate enlargement. Testicle shrinkage. Have all of these concerns prevented you from trying prohormones? On the other side, whispering in your ear like some haunting menace is the not-so-little voice that says, "Hey, chicken - squawk, squawk, squaaaawk - you're missing out on the best gains of your life. You'll never be as big and buff as you could be unless you get off the fence and do a cycle. C'mon... Do it!" First of all, let me put your mind at ease and let you know that everyone who decides to try steroids or prohormones at one point goes through similar mental gymnastics. The thought of being a big-boobed, bald, albeit muscular, dude with a prostate the size of a Swiss ball, is nothing less than frightening! Are these valid concerns, though? No, they're not, if you use good judgement, choose the right compound, and follow specific cycling parameters designed to avoid these problems. "Do you mean that I can really do a prohormone cycle that's safe?" I don't know the Vegas odds, but yeah, that's pretty much what I'm saying. Power Drive - Neurotransmitter Formula Up until now, bodybuilding science has spent all of its time trying to conquer the body while ignoring the brain. The trouble is, everything is controlled by the brain, and we're not just talking about memory or creativity or feelings of well being, either. The brain controls how well your muscles work. Ever wonder how some relatively weak-looking guys can rip apart phone books or bend steel rods in half? A lot of it has to do with muscle motor unit recruitment. Muscles are made up of individual motor units and some people are gifted in that they're able to recruit more of these motor units when it comes to performing an act of strength. Power Drive is designed to help you recruit more of these motor units so that you experience an almost immediate gain in strength and endurance. And, over the long run, this enhanced ability to recruit motor units results in bigger muscles. It stands to reason that, under normal circumstances, the average weight trainer doesn't even begin to work a good percentage of his or her muscle fibers. In effect, these fibers "sit by" during an average workout and receive very little direct stimulation. Without stimulation or recruitment, they won't respond by growing! The Power Drive formula is also designed to improve fat mobilization, along with concentration, memory, coordination, and endurance. It may, in some individuals, also increase pain threshold and overall sense of well-being. Lastly, Power Drive may prevent age-related decreases in testosterone levels. As you age, levels of a neurotransmitter called dopamine decrease, and this causes an increase in a hormone called prolactin. Unfortunately, increases in prolactin are accompanied by a decrease in testosterone. Power Drive may elevate dopamine levels, thus preventing the catabolic sequence. Biotest Surge Anabolic/Anti-Catabolic Formula Biotest Surge is designed to switch on anabolism and halt catabolism when it's absolutely most important - post workout. The formula stimulates a hormonal (primarily insulin) surge that drives high concentrations of certain nutrients, supplied by the drink, deep into the muscle cell. And if you're successful at achieving this cascade effect, you'll quash catabolism and stimulate anabolism, big time! In fact, it's estimated that you can speed up your body's ability to recover and build muscle by a minimum of one full day, which can make the difference between being the typical hard-gainer and at least a good-gainer. In reality, there're probably very few true hard-gainers. In fact, if you took everyone who's having a hard time making progress and just got them to consume ample amounts of the right mix of nutrients post workout, the vast majority would make consistent, continual muscle-mass gains. Really, it's that simple - and that hard. The hard part of effective post-workout nutrition is determining the right blend of nutrients in the ideal ratios. Well, we've done the research and testing, taking the guesswork out of the equation. There aren't many truths in bodybuilding, but one of them is this: post-workout nutrition is vital to your progress. If you don't get the right stuff into your body right after training, then you might as well not go to the gym and train hard. The solution for years has been to get some liquid protein down your gullet ASAP post-workout. That was a step in the right direction, but not perfect. The perfect post-workout drink would: 1) Maximize post-workout glycogen synthesis 2) stop protein breakdown that occurs during training 3) jack up the protein synthesis. Sorry to tell you this, but the shakes those front desk bimbos whip up for you at the juice bar don't cut it. Simply put, Biotest Surge is designed to switch on anabolism and halt catabolism. The drink causes a hormonal "surge" (primarily insulin) that drives the nutrients you need to grow, deep into the muscle cells. It also involves a very specific blend of certain specific amino acids that are crucial to its efficacy. Thus, it takes care of all three goals listed above. Reader feedback so far has been great: it tastes good and it works. Since the raw ingredients taste like tar on a hot summer day, Biotest Surge is another victory for the flavoring geniuses over at Biotest. Many people tried to formulate their own versions of Surge and most of it ended up being poured (or regurgitated) into the sink. Many users describe Biotest Surge as tasting like angel-food cake, which is pretty accurate. Even better than that is how quickly you'll notice improved recovery from your workouts. You'll be less sore and less fatigued. The lowdown: Helps you build muscle Helps preserve LBM while dieting Increases recovery and reduces soreness For men and women First-time purchases of a BIOTEST product are backed by a 100% money back guarantee. If you are dissatisfied with the product, contact us with the reason within 30 days of your date of purchase to receive a return authorization number. You will be instructed to return the unused portion and/or empty container at your expense for a refund of the product cost of one unit. Shipping charges are not refundable. T2 Thyroid Formula Written By Tim Patterson, Biotest Laboratories Announcing... T2... Believe it! I'm so excited, I feel like the time I "accidentally" walked into Arizona State's women's locker room and was treated to the sight of a dozen varsity cheerleaders in various degrees of undress. Well, maybe not quite that excited, but I am pumped to the max. We're finally producing the super powerful thyroid hormone... T2. We've been talking about making T2 for a long time, getting everybody's hopes up, but nothing seemed to be happening. What you didn't know is, we were working overtime in the background, trying to overcome a multitude of obstacles. All the problems centered on not being able to obtain the actual raw material - at least not efficiently. First off, the manufacturing plant in South America that makes the pharmaceutical-grade compound literally blew up. Fortunately, it was after working hours and no one was injured. Unfortunately, on the other hand, we had to wait for a new facility to be built and retooled, which took about six months. Finally, the plant was up and running and producing T2. But why all this fuss over one dietary supplement? It's very simple. T2 is the most potent non-prescription thyroid-hormone analogue available. In fact, in many aspects, it's equipotent to the big T3 (Cytomel). Even though T2 (3,5-diiodo-L-thyronine) is potentially suppressive if used long-term, it's still very safe when used at the recommended doses for periods of up to six weeks. But after that, to avoid the possibility of TSH suppression, you need to cycle off for six weeks In other words, it's not going to down-regulate thyroid production and leave your gland as inactive as a dormant volcano after you stop using it as long as you cycle off T2 for 6 weeks after 6 weeks of use. This is almost too good to be true! Now we can have all the metabolic stimulating horsepower of T3 in a safe dietary supplement. In fact, with all the volumes of research on T2 - as well as searching the FDA's archives - there isn't one single case of an adverse reaction reported from its use. Now that we've covered the safety issue, it's time to get into what's really exciting about T2. T2 is found abundantly in beef - you know, steak, hamburger, etc. - which clearly establishes that it's in our food supply and passes the FDA's supplement test. Our T2 isn't made from ground chuck, mind you, so don't freak out. It's highly pure material made in a pharmaceutical lab. If you're unfamiliar with T3, it's what the hardcore bodybuilders use in the final stages of contest prep to help them get that cellophane-thin skin that everyone wants, but few can obtain. In other words, without T3, most competitive bodybuilders would have an entirely different look, smoother to say the least. Of course, there are the select few who wouldn't need T3, but they are the rare exceptions. Ever since the super ripped look first appeared in the 80s, T3 has been widespread and universally used by the hardcore guys. But this leaves most of us law-abiding blokes pressing our noses against the metabolic windowpane, looking in at the privileged few who have access to T3. Yes, we have brand-new, cutting-edge thermogenics like MD6, but they only address half the metabolic challenge of getting lean, which is primarily through adrenoreceptor regulation. For example, MD6 contains compounds that effectively target both alpha and beta adrenoreceptors, control appetite even for the most avid gluttons (me), and elevate mood, making you as perky as Kathie Lee on speed. But, it doesn't provide the ability to switch on the body's real thermogenic powerhouses... thyroid receptors and the mitochondria. (In case you slept through biology class, like me, mitochondria are little critters that supply most of the aerobic fuel (ATP) for cells. In other words, activate them and you'll increase the metabolism, big time!) The Other Mr. T When we use the term "T," most often we're referring to Testosterone. But there's another powerful chemical family with that beloved moniker - Thyroid hormones. Thyroid hormones (TH) are considered major tissue growth factors. In fact, without them, overall body growth would not occur. They effect the activity of enzymes, the metabolism of substrates, vitamins and minerals, and the function of other endocrine systems. In essence, thyroid hormones stimulate basal metabolic rate by increasing whole-body oxygen consumption, which is activated through two different pathways: DNA transcription on various target tissues (heart, liver, muscle, etc.), and by acting directly upon the mitochondria. The effect on the mitochondria is particularly interesting. Even though the mechanism isn't fully understood, it's believed thyroid hormones act as uncoupling agents, releasing energy through the production of ATP. Additionally, thyroid hormones... Stimulate protein synthesis (Can you say Anabolic!?) Affect most every aspect of carbohydrate metabolism Produce multiple effects on lipid metabolism, especially lipoproteins ("cholesterol") Enhance the effects of epinephrine in stimulating glycogenolysis and glucose utilization As you can see, thyroid hormones are powerful metabolic allies to have on your side. And, in contrast, if you're thyroid deficient, you're dead meat, bubba. In today's world, with all the crazy dieting schemes and thermogenic compounds being used by just about everyone, it's a safe bet that most of our T glands are a little sluggish. But that doesn't have to be the case. Now we have a legal, as well as safe, over-the-counter thyroid hormone with just as much punch as the big guy himself, T3. Of course, the thyroid hormone I'm referring to is T2. And just because 2 is one less than 3, don't let that fool you. Remember, T4 is much weaker than T3, so the number scheme doesn't reflect the potency of the analogue. All this is pretty cool stuff, but how does T2 actually stack up to T3? Ready to be very impressed? T2 Compared to T3 The similarity between T2 and T3 is remarkable - both in structure as well as activity in the body. Just take a look at the respective chemical names: T2: diiodothyronine (3,5-diiodo-l-thyronine) T3: triiodothyronine (3,5,3'-triiodo-l-thyronine) Not a chem buff? That's okay, there's tons of scientific literature that compares the actions of T2 to T3. When I began to delve into the research, the more I read about T2 the more excited I became. In fact, I'm so impressed with T2, I don't plan on using T3 ever again. And, if what follows doesn't give you wood, nothing will. Here's what I found: T2 is as effective as T3 at activating hepatic malic enzyme (ME), but it's 3-5 times more effective at activating liver glucose-6-phosphate dehydrogenase (G6PD). T2 has much more of a pronounced effect on the mitochondria than T3 on four metabolically very active tissues: brown-adipose tissue, skeletal muscle, the liver, and heart muscle. T2 boosts GH identical to T3, which is a 5-fold increase (demonstrated in hypothyroid rats). T2 directly targets cytochrome-C reducers and cytochrome-C oxidizers, thus significantly stimulating mitochondrial respiration. This means T2 plays a role where rapid-energy utilization is required, such as cold exposure or overfeeding (pigging out). Bottom line is, T2 is every bit as potent as T3, which means you now have an over-the-counter supplement that can truly maximize actual thyroid function just as effectively as the prescription drug Cytomel (T3)! And Biotest is the one delivering it, which makes us feel pretty darn good. We've made a commitment to produce products that work nearly as well, or as well, as the popular, illegal drugs of bodybuilding. And with T2, we hit the "as good as drugs" category. Biotest T2 is, without a doubt, the single, most-potent compound for fat loss ever to be released in the supplement industry. In fact, it's so effective that we have concerns about what the FDA's going to do. Yes, we have attorneys who have given us the go-ahead, but you know the FDA... It's their way or the highway. Getting Truly Lean and Buff This is where I give a strong dose of reality. If you're as fat as a manatee, don't expect to take T2 and be able to do ab poses at the beach in a week. It should be obvious, the further you are away from being ripped, the longer it's going to take to get there. To put it in perspective, if you have 20 pounds of fat to lose - the basic 2-pack look - you better know that it's going to take at least two months to get super lean, that is if you have the genetics, and if you don't metabolize a bunch of muscle in the process. To get truly lean, you have to make a commitment to pay careful attention to manipulating diet and post-workout nutrition, tweaking training, and using drugs and/or supplements that accelerate fat loss and maximize muscle gains. Don't misunderstand me. I'm not saying that you should expect to gain a lot of muscle while cutting up. All I'm saying is that you have to use anabolic agents at this time to preserve muscle mass, and maybe even gain a pound or two. In other words, regarding your physique, getting exceptionally lean is probably the single most difficult endeavor you'll encounter. I'm convinced that it's utterly impossible to get really lean and buff without the use of powerful compounds to rev up the metabolism, and anabolics to keep from losing muscle mass. If purebred bodybuilders have to do it that way, we do too. So, in your quest for cellophane-thin skin, don't forget to include anabolics. In the steroid world, in my opinion, we're talking about trenbolone acetate, stanozolol, oxandrolone, and injectable 4-AD. And for those who want to stay legal, the best choices are Androsol, Nandrosol, Tribex-500, and Methoxy-7. In summary, to get that ripped, muscular-hard look of a bodybuilder, you need to stack a potent adrenoreceptor thermogenic, like MD6, with T2 and anabolics. Without this super-stack arsenal, don't expect these kinds of results. You can get lean, but not that lean. First-time purchases of a BIOTEST product are backed by a 100% money back guarantee. If you are dissatisfied with the product, contact us with the reason within 30 days of your date of purchase to receive a return authorization number. You will be instructed to return the unused portion and/or empty container at your expense for a refund of the product cost of one unit. Shipping charges are not refundable.

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