MET-Rx Protein Plus Bars Athlete's and active people on all levels require a higher protein intake than the average person - and the Protein Plus bar is one of the best-tasting, most convenient ways to get that extra protein. Protein Plus bar is a high protein supplement bar with over 30 grams of high quality METAMYOSYN enhanced protein. It's Easily Digested And Absorbed. The PROTEIN PLUS FOOD BAR From MET-RX - The Best Thing, Most Convenient Way To Get The Extra Protein You Need Without Unwanted Carbohydrates. Protein Plus Cereal A high protein breakfast cereal that tastes great. Energy that lasts! Many athletes have discovered that high protein diets provide energy that lasts. They use the Zone Diet combination: 40% carbohydrates, 30% protein, and 30% fat. Independent studies from Pepperdine University and Sansum Medical Research Foundation in Santa Barbara, California demonstrated that the 40-30-30 formula improved athletic performance and aided in weight loss. Nobody would eat sugar-covered bread for lunch or dinner, but it's the only option in the cereal aisle. Popular cereals are just different shapes and colors of the same food: carbohydrates. And, carbohydrates digest quickly, leaving you hungry. Protein digests slower giving you sustained energy and keeping you full. Eat Protein Plus cereal with whole milk and almonds to achieve that optimal 40-30-30 combination. Or, eat Protein Plus cereal with skim milk as a low-fat option. 1-T Ethergels Molecular Nutrition's new 1-T Ethergels contain the steroidal nutrient 1-testosterone tetrahydropyranyl (THP ether), dissolved in sesame oil and sealed in a soft gelatin capsule for maximum lymphatic system absorption, oral bioavailability and anabolic effect. This type of delivery vehicle is absolutely essential for ether-modified hormones, as it allows for a level of absorption many times greater than simply putting the compound in a regular hard-shell capsule. 1-T Ethergels are the first in a revolutionary line of new oil-solubilized, softgel encapsulated prohormones from Molecular that promise to tackle, once and for all, the issue of poor prohormone bioavailability. 1-Testostrerone THP ether (5a-androst-1-ene-3-one,17-tetrahydropyranyl) 1-Testosterone (5a-androst-1-ene-3-one,17b-ol) ...the first in a revolutionary line of new prohormones from Molecular that promise to tackle, once and for all, the issue of poor prohormone bioavailability. ETHER-MODIFIED 1-TESTOSTERONE Ether-Modification is a breakthrough in the field of steroidal nutrients, as it allows us to drastically increase the oral bioavailability of hormonal supplements by altering the way they are absorbed by the body. The technology works by attaching an ether molecule to a steroidal hormone, which tremendously increases its lipophilic (fat-soluble) nature. This allows much of the active hormone to bypass the destructive first-pass through the liver, and instead enter circulation, intact, through the lymphatic system. With this technology there is simply no longer a need for high doses or alternate forms of delivery! SUPERIOR SOFTGEL FORMULATION But if we just put our 1-Testosterone ether in a regular capsule we would have wasted its true potential! Maximum lymphatic absorption is achieved only when the ether-modified hormone is dissolved in a proper oily vehicle. The graph below illustrates this significance extremely well with mepitiostane, an ether-modified form of the steroid epitiostanol. Here steroid absorption by the lymphatic system was more than 5 times greater when dissolved in sesame oil rather than a water-based solution. This is a monumental difference, and the reason our softgels use exactly sesame oil as their vehicle. With unquestionably the best possible oral absorption and anabolic potency of any steroidal nutrient on the market, our 1-T EtherGels are without doubt the ultimate 1-testosterone supplement, Hands Down! absorption by the lymphatic system was more than 5 times greater when dissolved in sesame oil Figure 1. Differences in lymph absorption when ether-modified steroid is administered in sesame oil vs. a water-based vehicle to the small intestine of rats. SOURCE: Effect of oily vehicles on absorption of mepitiostane by the lymphatic system in rats. Ichihashi T, Kinoshita H, Takakishi Y, Yamada H. J Pharm Pharmacol 44 (1992) 560-4. A NATURALLY OCCURRING HORMONE 1-Testosterone (5a-androst-1-ene-3-one,17b-ol) is an androgen metabolite found in humans. It is similarly a natural compound that can legally be sold as a nutritional supplement. References: [i] In vivo uptake and metabolism of 3b-5a-androstane-3a,17b-diol and of 3b-5a-androstane-3b,17b-diol by human prostatic hypertrophy. Horst, Dennis, Kaufmann and Voigt. Acta Endocrinol Vol. 79 (1975) 394-402 [ii] Aromatization of androgens to estrogens mediates increased activity of glucose 6-phosphate dehydrogenase in rat levator ani muscle. Endocrinol 106(2):440-43 1980 [iii] Activation of the somatotropic axis by testosterone in adult males: Evidence for the role of aromatization. Weissberger and Ho. J Clin Endocrinol Metab 76 (1993) 1407-12 [iv] Modulation of the cytosolic androgen receptor in striated muscle by sex steroids. Rance, Max. Endocrinol 115 (1984) 862-6 [v] In vivo androgen in rat skeletal and perineal muscles. Dionne, Dube, Lesage and Tremblay. Acta Endocr Copen. 91 (1979) 362-72 3-Alpha 3-Alpha (5alpha-androstane-3alpha, 17beta-diol) contains the brand new 3-alpha isomer of 5alpha-androstanediol, a direct precursor to the extremely potent non-aromatizable (no estrogen) androgen dihydrotestosterone. It has a documented active blood conversion rate of 43%, a value four and a half times greater than the old 3-beta isomer. 3-Alpha is the ultimate body sculpting agent, excellent for enhancing muscle hardness, definition, strength and the overall look of solid muscularity. U.S. Patent # 6,242,436 Just as there is a clear need for aromatizable anabolic steroid hormones, particularly when muscle mass is the primary focus, there also exists a strong need for non-aromatizable compounds: Androgens that do the specific job of hardening and tightening the physique. Just ask any serious bodybuilder where he would be without this class of steroid at contest time. The non-aromatizable androgen is often indispensable to building a winning show physique. Recently this class of agent has been explored in the supplement market, and 3-Alpha (5a-androstane-3a,17b-diol) represents the greatest achievement in this area of research as it is both a direct precursor to the most potent androgen found in humans (dihydrotestosterone) and by far the most active in terms of documented blood conversion rate. The chemical structures of both are: 3-Alpha (5a-androstane-3a,17b-diol) Dihydrotestosterone (5a-androstane-3-one,17b-ol) 3-Alpha is unquestionably the most potent non-aromatizable androgenic prohormone ever developed, the ultimate hardening, cutting and strength promoting agent. The Highest Documented Conversion Rate 3-Alpha is not only an incredibly potent product because it converts to the powerful androgen dihydrotestosterone, but also because it is activated with an affinity far exceeding any other prohormone. 4-androstenedione and 4-androstenediol for example have demonstrated a conversion rate to testosterone of roughly 5.5% and 16% respectively. The 3-beta isomer of 5-alpha androstanediol, the predecessor to 3-Alpha, stands at about a 9.5% conversion rate to dihydrotestosterone. Although these figures are fair, they fall far short of the 43% conversion rate demonstrated in in-vivo human studies with 3-alpha[i]. A blood conversion rate this high is clearly unprecedented, making 3-Alpha a serious step up from the less active prohormones to come before it. Figure 1 compares the active conversion rates of the mentioned compounds. ...43% conversion rate demonstrated in in-vivo human studies with 3-alpha. A blood conversion rate this high is clearly unprecedented... Figure 1. 4-Androstenedione and 4-Androstenediol: The amount of testosterone formed after incubation in human blood. Acta Endocrinol vol. 55 697-704. 3-beta and 3-alpha isomers of 5alpha-androstanediol: The amount dihydrotestosterone formed in serum after injection into human subjects. Acta Endocrinol Vol. 79 (1975) 394-402. No Aromatization 3-Alpha will not raise estrogen levels in the body, as it lacks the necessary structure for aromatization (androgen to estrogen conversion) to be possible. Its activity in the body is that of a pure androgen, and similarly side effects related to estrogen such as increased body fat, water retention and gynecomastia are not possible during use. Dihydrotestosterone is further shown to have anti-estrogenic activity, an added benefit when we are looking to lower the activity of this hormone in the body. Although some estrogen is desirous when we are looking to build mass, due to the fact that androgens and estrogens play opposing roles on the deposition of body fat in humans its absence is preferred when we are trying to 'cut-up'. With this in mind bodybuilders will often use non-aromatizable steroids such as stanozolol, methenolone, trenbolone, fluoxymesterone, Proviron (mesterolone; 1-methyl DHT) and Masteron (drostanolone; 2-methyl DHT) exclusively during contest season. As a natural supplement of this type, 3-Alpha is the ultimate body-sculpting agent. Unmatched in its capacity to improve muscle hardness, definition and the overall look of solid muscularity often unattainable with estrogenic prohormones. Anabolic Activity and Muscle Tissue Conversion Dihydrotestosterone is not the best bulking agent for two reasons. First, it is non-estrogenic, and estrogenic activity seems to be an integral property of every good mass-building steroid. This is likely due to the interactions between estrogen and muscle glucose utilization[ii], growth hormone secretion[iii] and androgen receptor proliferation[iv]. So if bulk is the goal, then you probably do not want to use non-aromatizable prohormones exclusively. Dihydrotestosterone is also very open to the 3alpha-hydroxysteroid dehydrogenase enzyme, present in large amount in skeletal muscle tissue[v]. This works to rapidly deactivate DHT as it enters these cells by converting it to its metabolite (and precursor) 3-Alpha. This normally allows for poor androgen binding in muscle tissue, and a weak anabolic response. It would be incorrect to say that DHT was devoid of anabolic activity however, as it still exerts some activity in muscle. Interesting also is that fact that studies with 3-alpha note an unexpectedly high recovery of dihydrotestosterone in muscle tissue after administration. Although the 3A-HSD enzyme still appears to be preferential in its deactivation of DHT in this area of the body, we see a remarkable 23% conversion rate of 3-Alpha to dihydrotestosterone here. This is likely due to the fact that 3-Alpha relies on the same enzyme for activation that dihydrotestosterone does for deactivation, and as it enters muscle cells an opposite trend develops toward dihydrotestosterone buildup. Although not the preferred bulking agent, 3-Alpha does appear to have measurable anabolic potency, and is effective at promoting lean muscle tissue growth. Strength gains are also substantial, and especially profound in relation to overall bodyweight gain. ... [3-Alpha has] measurable anabolic potency, and is effective at promoting lean muscle tissue growth. Strength gains are also substantial, and especially profound in relation to overall bodyweight gain. DHT and Androgenic Side Effects It is a terrible misconception among bodybuilders that dihydrotestosterone is an isolated culprit when it comes to side effects. All anabolic/androgenic steroids exert their activities through the cellular androgen receptor, and dihydrotestosterone is no different than any other agent except that it is a more potent activator of this receptor than most. All steroids can cause androgenic side effects in direct relation to their affinity for this receptor, and DHT has no known unique ability in this regard. That said, those with a known or apparent genetic predisposition to hair loss for example would not be advised to take a strong androgenic prohormone if they wish to avoid advancing this condition. But again, 3-Alpha joins a long list of prohormones with similar potential (none are truly devoid of this possibility). For the vast number of others willing to experiment with prohormones, one would expect the typical androgenic side effects such as oily skin, acne or body and facial hair growth to occur with 3-Alpha in relation to the dosage used and ones own individual sensitivity. A Naturally Occurring Hormone 3-Alpha (5-alpha androstane-3alpha,17beta-diol) is an androgen metabolite found in humans. It is similarly a natural compound that can legally be sold as a nutritional supplement. References: [1] Metabolism of 1-dehydroandrostanes in man. I. Metabolism of 17-beta-hydroxyandrosta-1,4-dien-3-one, 17-beta-cyclopent-1-enyloxyandrosta-1,4-dien-3-one (quinbolone) and androsta-1,4-dien-3-one (1). Galletti F and Gardi R. Steroids 18 (1971) 39-50. [2] Metabolism of 1-dehydroandrostanes in man. III. Metabolism of 17-beta-hydroxy-5a-androst-1-en-3-one, 17-beta-(1-methoxy-cyclohexyloxy)-5-a-androst-1-en-3-one (mesabolone) and 5a-androst-1-en-3,17-dione. Galletti F and Gardi R. J Steroid Biochem 3 (1972) 933-6. [3] Biosynthesis of Estrogens, Gual C, Morato T, Hayano M, Gut M and Dorfman R. Endocrinology 71 (1962) 920-25 [4] Aromatization of androgens to estrogens mediates increased activity of glucose 6-phosphate dehydrogenase in rat levator ani muscle. Endocrinol 106(2):440-43 1980 [5] The pentose phosphate pathway in regenerating skeletal muscle. Biochem J 170: 17 1978 [6] Activation of the somatotropic axis by testosterone in adult males: Evidence for the role of aromatization. Weissberger and Ho. J Clin Endocrinol Metab 76 (1993) 1407-12. [7] Modulation of the cytosolic androgen receptor in striated muscle by sex steroids. Rance, Max. Endocrinol 115 (1984) 862-6 [8] Metabolism of Beldenone in Man: gas Chromatographic/Mass Spectrometric Identification of Urinary Excreted Metabolites and Determination of Excretion Rates. Schanzer, Donike. Bol Mass Spec. 21 (1992) 3-16 [9] Identification of C19 Steroids in Bovine Feces. Miller, W.R., C.W. Turner, D.K. Fukushima and I.I. Salamon: J. Biol. Chem. 1956 220: 221 [10] The in-vitro metabolism of progesterone-c14 to Delta-1,4-Androstadiene-3,17-dione by a cystic bovine ovary. Gawienowski A. M., Lee S.L. and Marion G.B.: Endocrinology 69 (1961) 388-90. [11] C. J. M. Arts, R. Schilt, M. Schreurs and L.a. Van Ginkel, in Proceedings of the Euroresidue III Conference, Veldenhoven, 6-8 May 1996 ed. N. Haagsma and A. Ruiter, University of Utrecht, Utrecht, The Netherlands, 1996, p. 212 Boldione Boldione (1,4 androstadienedione) is a revolutionary new orally active prohormone to the powerful anabolic steroid boldenone. The unique structure of this compound makes it far more resistant to first-pass liver metabolism than literally every other prohormone on the market, allowing it to display a level of oral bioavailability unprecedented in a legal prohormone. Combined with its potent anabolic nature, Boldione is the ultimate legal anabolic. Boldione (1,4-androstadiene-3,17-dione) is the lead innovation to arise out of the next generation of orally active prohormones. It is a direct precursor to the anabolic steroid boldenone, and displays a level of oral bioavailability far superior to any other compound, including the new 1-androstenes. If you are unfamiliar with boldenone, it is an anabolic steroid most often found in injectable form as a veterinary medication (boldenone undecylenate). It is chemically a derivative of testosterone, characterized as a strong anabolic and low to moderately androgenic agent. As its name indicates, Boldione is simply the 'dione' form of boldenone, activated in the body by the same widely distributed 17beta-hydroxysteroid dehydrogenase enzyme that converts androstenedione to testosterone. The chemical structures of both are: Boldione (1,4-androstadiene-3,17-dione) Boldenone (1,4-androstadiene-3-one,17b-ol) Boldione is truly the most advanced and potent anabolic prohormone ever developed, exhibiting several undeniable advantages over competing products: The Most 'Orally Active' Prohormone Boldione is unquestionably the most orally active prohormone ever developed. As you probably know, poor oral bioavailability is one of the most fundamental problems with prohormones. The liver processes natural steroid hormones so efficiently, that when taken orally little will make its way all the way through to the blood stream in active from. All but a small percentage of the steroid will typically be found as an inactive 17-keto steroid. Here the 17 beta-hydroxyl group, vital to androgen binding, is removed and the compound rendered inactive. To solve this problem with pharmaceutical agents, chemists have synthetically altered most oral steroids with some form of 17-alpha alkylation (typically a methyl or ethyl addition), which virtually inhibits 17-ketosteroid reduction by occupying a carbon bond necessary for this reaction. But this type of alteration is also toxic to the liver, synthetic, and clearly not possible to use with natural prohormones. The structure of Boldione however is intrinsically resistant to 17-ketosteroid deactivation during this first pass through the liver. The combination of its delta 1 and delta 4 double bond (1,4-Di Ene) shifts the hepatic metabolism (the 17-keto redox potential) of this compound far in favor of activation. This is made clear by studies showing Boldione to produce by far the most profound excretion of active 17beta-hydroxysteroids we have seen of any prohormone, as much as 50% of recovered urinary metabolites [1] . Surprisingly the 17beta-hydroxyl group survives hepatic metabolism to an enormous degree. Although this is not the near 100% recovery you would expect with a synthetic agent, it is amazingly superior (by far) to every other prohormone ever developed including the 1-androstene's [2] . ...by far the most profound excretion of active 17beta-hydroxysteroids of any prohormone, as much as 50% of recovered urinary metabolites... Figure 1 compares the 17-beta hydroxysteroid recovery of 4-androstenedione, the new 1-androstenedione, and Boldione (1,4-androstadienedione). As you can see, the delta 1 bond alone increases active metabolite recovery considerably. However when we add the additional delta 4 bond, the recovery is far more dramatic. Figure 1. Average percentage of 17beta-hydroxysteroid metabolites recovered from human urine after 4-Androstenedione injection (J. Biol Chem 239(1964) 1578-84), 100mg oral 1-androstenedione (J Steroid Biochem 3 (1972) 933-6) and 100mg oral 1,4-androstadienedione (Steroids 18 (1971) 39-50). Favorable Aromatization Boldione converts to estrogen at roughly half the rate of androstenedione and testosterone [3] . This significantly reduces the level of estrogen buildup during use compared to that achieved with testosterone precursors, and similarly also lowers the chance of noticing strong estrogen related side effects such as increased body fat, gynecomastia and definition hiding water retention. It is no coincidence that the best bulking agents are estrogenic though, as this hormone does offer more than just side effects. Aside from the basic size increase we would attribute to fluid retention, estrogen also aids the muscle building process by enhancing glucose utilization for tissue growth and repair [4] [5] , increasing growth hormone secretion [6] and perhaps even by increasing androgen receptor concentrations [7] . It is clear today that estrogen serves a positive function in muscle growth, finally allowing us to explain a well known anecdotal fact: Aromatizable steroids are always the strongest muscle-builders, and preferred over non-aromatizable steroids when mass is desired. Boldione coverts to estrogen at a high enough rate to support excellent muscle gains, yet is typically mild enough to promote quality, defined growth without unwanted side effects. The long and fond relationship bodybuilders have had with boldenone is a clear testament to this fact. ... estrogen also aids the muscle building process by enhancing glucose utilization for tissue growth and repair, increasing growth hormone secretion and perhaps even by increasing androgen receptor concentrations... Reduced Androgenic Activity Boldenone is classified as an anabolic steroid, exhibiting much less androgenic activity than its analogue testosterone. This is because unlike testosterone, boldenone is a poor substrate for the 5-alpha reductase enzyme [8] . This is the enzyme responsible for converting testosterone to the more potent steroid dihydrotestosterone in many androgen responsive tissues such as the skin, scalp, prostate and central nervous system. Consequently the local potency of testosterone is increased significantly in these tissues, often allowing it to trigger unwanted side effects such as oily skin, acne, body/facial hair growth and male pattern hair loss (for those with a genetic predisposition). But boldenone tends to interact with the 5-beta reductase enzyme instead, which reduces this steroid into a very weak binder of the androgen receptor instead of potentiating its activity. Consequently boldenone is much milder in terms of androgenic side effects compared to testosterone, being much more similar to nandrolone in this regard. A Naturally Occurring Hormone In order for any prohormone to be classified as a nutritional supplement, the compound in question must be 'naturally occurring'. This means that we must isolate a clear source for it in nature, without human synthesis. Thankfully 1,4-androstadienedione was shown unquestionably to be a natural androgen in cows. The first study to isolate this compound was conducted back in 1956, where scientists believed that it was most likely produced from progesterone in the animal's gastrointestinal tract [9] . Later studies show the production of this hormone in cow ovarian tissues however [10] , suggesting another location and method of endogenous production. We can also look toward studies in the agricultural industry, where the natural occurrence of 1,4-dienones [11] have caused some difficulty and debate over the screening processes used for detecting the illegal use of boldenone in cattle. Many have suggested threshold limits to prevent false positives due to the low level of 1,4-diene androgens that may be present naturally in these animals.

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